Dr. Tom N. Grossmann

Professor of Organic Chemistry

VU University Amsterdam
Dept. of Chemistry & Pharmaceutical Sci.
De Boelelaan 1108
1081 HZ Amsterdam
The Netherlands

Chemical Genomics Centre (CGC)
of the Max Planck Society
Otto-Hahn-Str. 15
44227 Dortmund
Germany

Email: t.n.grossmann@vu.nl

ResearcherID: A-4175-2015

Curriculum Vitae

GA

Perspective in Cell Chemical Biology is online

By grossmannlab on Nov 17, 2017

“The therapeutic potential of PTEN modulation: Targeting strategies from gene to protein”

NM McLoughlin, C Mueller, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.10.009

untitled

Article in Chemistry – A European Journal is online

By grossmannlab on Oct 20, 2017

“Oligonucleotides with cationic backbone and their hybridization with DNA: Interplay of base pairing and electrostatic attraction”

B Schmidtgall, A Kuepper, M Meng, TN Grossmann*, C Ducho*, DOI: 10.1002/chem.201704338

Graphical Abstract

Article in the Journal of Medicinal Chemistry is online

By grossmannlab on Oct 14, 2017

“Structure-based design of macrocyclic peptides that inhibit protein-protein interactions”

DM Krüger, A Glas, ,* ,* TN Grossmann*, DOI: 10.1021/acs.jmedchem.7b01221

Chem_cover

Communication in Chemistry – A European Journal is online

By grossmannlab on Aug 5, 2017

This communication is featured on the inside cover.

“Increased conformational flexibility of a macrocycle‒receptor complex contributes to reduced dissociation rates”

A Glas, EC Wamhoff, DM Krüger, C Rademacher*, TN Grossmann*, DOI: 10.1002/chem.201702776

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Article in Cell Chemical Biology is online

By grossmannlab on Jul 27, 2017

“Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets b-Catenin Protein-Protein Interactions”

L Dietrich, B Rathmer, K Ewan, T Bange, S Heinrichs, TC Dale, D Schade, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.06.013

We thank our collaborators for their contributions!!

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Congratulations to Laura Dietrich

By grossmannlab on Jul 25, 2017

Laura successfully defended her PhD thesis “Zellgängige Peptide zur Inhibition des Wnt/β-Catenin Signalwegs”.

EU research

Our work was highlighted in the latest issue of EU Research

By grossmannlab on Jul 22, 2017

Combining the best of small molecules and biologics (page 12)

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Article in Nature Communications is online

By grossmannlab on Mar 23, 2017

Congratulations to the Dissmeyer and Flashman labs and thanks for having us onboard!

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets”

MD White, M Klecker, R Hopkinson, D Weits, C Mueller, C Naumann, R O’Neill, J Wickens, J Yang, JC Brooks-Bartlett, EF Garman, TN Grossmann, N Dissmeyer*, E Flashman*, DOI: 10.1101/ncomms14690

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Poster prizes for Kerstin Wallraven and Adrian Glas

By grossmannlab on Mar 22, 2017

Congratulations to Kerstin and Adrian who recieved prizes for their proster presentations at the German Peptide Symposium!

angewandte

Review in Angewandte Chemie is online

By grossmannlab on Feb 10, 2017

Congratulations to the entire AztraZeneca/MPI satellite team!

“New modalities for challanging targets in drug discovery”

E Valeur,* SM Gueret, H Adihou, R Gopalakrishnan, M Lemurell, H Waldmann, TN Grossmann, AT Plowright, DOI: 10.1002/anie.201611914

Niall & Mathias (wide)

Niall McLoughlin and Mathias Wendt (re)join our team

By grossmannlab on Jan 2, 2017

Welcome, Niall and Mathias! All the best for your PhD research!

Translocation of an intracellular protein via peptide-directed ligation

Article in ACS Chemical Biology is online

By grossmannlab on Dec 21, 2016

“Translocation of an intracellular protein via peptide-directed ligation”

C Stiller, DM Krüger, N Brauckhoff, M Schmidt, P Janning, H Salamon, TN Grossmann*, DOI: 10.1021/acschembio.6b01013

Christmas '16 (wide)

Merry Christmas!

By grossmannlab on Dec 20, 2016

We wish you a merry Christmas and a happy New Year!

Christiane

Congratulations to Christiane Stiller

By grossmannlab on Dec 8, 2016

Christiane successfully defended her PhD thesis “Peptid-vermittelte chemische Modifikation intrazellulärer Proteine”.

Adrian successfully defended his PhD thesis

Congratulations to Adrian Glas

By grossmannlab on Sep 22, 2016

Adrian successfully defended his PhD thesis “Kohlenwasserstoff­verbrückte Peptide mit irregulärer Sekundärstruktur für die Inhibition von Protein-Protein-Interaktionen”.

Constraining an irregular peptide secondary structure via ring-closing alkyne metathesis

Communication in ChemBioChem is online

By grossmannlab on Sep 6, 2016

“Constraining an irregular peptide secondary structure through ring-closing alkyne metathesis”

PM Cromm, K Wallraven, A Glas, D Bier, A Fürstner, C Ottmann, TN Grossmann*, DOI: 10.1002/cbic.201600362

Technische Universität Dortmund

Congratulations to Philipp Cromm

By grossmannlab on Jun 28, 2016

Philipp successfully defended his PhD thesis “Design und Synthese Peptid-basierter Inhibitoren für Protein-Protein-Interaktionen”.

Inside Cover: Angew. Chem. Int. Ed. Volume 55, Issue 36 (2016)

Communication in Angewandte Chemie is online

By grossmannlab on Jun 28, 2016

Congratulations to the Etzkorn lab and thanks for having us onboard. This communication is featured on the inside cover.

“Selective protein hyperpolarization in cell lysates using targeted dynamic nuclear polarization”

T Viennet, A Viegas, A Kuepper, S Arens, V Gelev, O Petrov, TN Grossmann, H Heise, M Etzkorn*, DOI: 10.1002/anie.201603205

Cover: ACS Chem. Biol. Volume 11, Number 8 (2016)

Article in ACS Chemical Biology is online

By grossmannlab on Jun 23, 2016

This article is featured on the cover.

“Protease-resistant and cell-permeable double-stapled peptides targeting the Rab8a GTPase”

PM Cromm, J Spiegel, P Küchler, L Dietrich, J Kriegesmann, M Wendt, RS Goody, H Waldmann*, TN Grossmann*, DOI: 10.1021/acschembio.6b00386

Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides

Article in Nature Communications is online

By grossmannlab on Apr 14, 2016

“Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides”

PM Cromm, S Schaubach, J Spiegel, A Fürstner*, TN Grossmann*, H Waldmann*, DOI: 10.1038/ncomms11300